Good news for hair loss Hair protein targeting technology reduces hair loss by 90% [Science Now]
A research team at the Korea Advanced Institute of Science and Technology (KAIST) focused on the possibility that tannic acid, a type of natural polyphenol, could contribute to hair loss prevention, and through research, discovered that tannic acid is not a simple coating agent, but acts as an 'adhesion mediator' that alleviates hair loss.
KAIST (President Lee Kwang-hyung) announced on the 6th that Professor Hae-shin Lee's research team in the Department of Chemistry developed a new hair loss prevention technology that slowly releases a hair loss alleviation functional ingredient using a tannic acid-based coating technology.
Tannic acid is a polyphenol compound that contains a galol group that has a 360-degree adhesive function, and it binds to the hair surface on one side and binds to the hair loss alleviation functional ingredient SCANDAL on the other side to store it on the hair surface. [Photo = KAIST]
Hair loss includes androgenetic alopecia (AGA) and telogen effluvium (TE), and genetic, hormonal, and environmental factors work together. Currently, there is a lack of effective treatments with few side effects.
Representative hair loss treatments, minoxidil and finasteride, show a certain effect, but require long-term use, and not only do their effects vary depending on the body type, but some users also experience side effects. Professor
Lee Hae-shin's research team proved that tannic acid can strongly bind to keratin, the main protein in hair, and can be continuously attached to the hair surface. Using this, they confirmed that specific functional ingredients can be released in a controlled manner.
The research team developed a combination that included hair loss relief functional ingredients such as salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL), and named it 'SCANDAL.'
The research results showed that the Scandal complex combined with tannic acid is gradually released when it comes into contact with moisture and is delivered to the hair follicles along the hair surface.
The research team at Goodmoon Clinic (Director Lee Geon-min) applied shampoo containing tannic acid and Scandal complex to 12 hair loss patients for 7 days, and a significant hair loss reduction effect was observed in all of the clinicians.
The results of the experiment showed an average hair loss reduction effect of 56.2%, and there were cases where hair loss was reduced by up to 90.2%.
This suggests that the method in which tannic acid stably maintains the Scandal component on the hair surface and is gradually released and delivered to the hair follicles can be effective in alleviating hair loss.
Professor Lee Hae-shin said, "We have successfully proven that tannic acid, a type of natural polyphenol, has a strong antioxidant effect and has the property of strongly binding to proteins, so it can act as a bioadhesive."
He continued, "There have been cases in previous studies where it was utilized as a skin and protein coating material, but this study is the first case of combining with hair and delivering hair loss alleviation ingredients, and we applied it to 'Grabity' shampoo commercialized through Polyphenol Factory, a teaching startup." He continued, "We are continuing to work on commercializing more diverse research results, such as a shampoo that dramatically increases the strength of thin hair that tends to break, and a product that straightens curly hair."
The results of this study (paper title: Leveraging Multifaceted Polyphenol Interactions: An Approach for Hair Loss Mitigation), in which KAIST Department of Chemistry Ph.D. candidate Kim Eun-woo was the first author and Professor Lee Hae-shin participated as the corresponding author, were published online in the January 6th issue of the international academic journal 'Advanced Materials Interfaces.'
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